61. Anemia Drugs Under Scrutiny Mar 13, 2008 U.S. drug regulators are contemplating further restrictions on the use of drugs to combat anemia in cancer patients. http://www.physorg.com/news124619700.html

PhysOrg Account: Sign In Sign Up Home Nanotechnology ... All subcategories Published: 09:35 EST, March 13, 2008 Toolbox Rating: n/a Bookmark Save as PDF Print Email Blog It Digg It del.icio.us Slashdot It! Stumble It! Anemia drugs under scrutiny U.S. drug regulators are contemplating further restrictions on the use of drugs to combat anemia in cancer patients. The newspaper said eight clinical trials have suggested the drugs might make tumors worse or shorten the life of cancer patients. One FDA adviser last year called the drugs "Miracle-Gro for cancer." Researchers said the anemia drugs are synthetic forms of a human hormone called erythropoietin, or Epo, that is involved in the production of red blood cells. Epo may encourage the growth of blood vessels that nourish tumors or may actually stimulate tumors directly, scientists said. Another theory is that Epo protects tumors from being destroyed by chemotherapy. Amgen said it has not seen any convincing evidence Epo does anything but spur red blood cell production, the newspaper said. Ibuprofen destroys aspirin's positive effect on stroke risk would you recommend this story?

62. Log In Problems Mar 14, 2008 Erythropoiesisstimulating agents should continue to have an oncology indication, even though questions about their safety remain. http://www.medscape.com/viewarticle/571464

Medscape eMedicine Medscape CME Medscape Connect ... CLOSE [X] SPECIALTY SITES Cardiology Critical Care Dermatology Emergency Medicine ... Women's Health OTHER SITES Business of Medicine Medscape Today Med Students Nurses ... Viewpoints Unable to Deliver Requested Page In order to use Medscape, your browser must be set to accept cookies delivered by the Medscape site. To find out how to adjust your browser settings to accept cookies, please click here Medscape uses cookies to customize the site based on the information we collect at registration. The cookies contain no personally identifiable information and have no effect once you leave the Medscape site. You can read more about our use of cookies in our All Medscape eMedicine Drug Reference ... Contact Us document.write('')

63. Amgen And JNJ's Anemia Drug Showdown - Seeking Alpha Mar 12, 2008 Anyway, Dr. Perlmutter repeated at least three times that he believes the benefits of Amgen s drugs for chemoinduced anemia are http://seekingalpha.com/article/68295-amgen-and-jnj-s-anemia-drug-showdown

Seeking Alpha Investment Ideas Cramer's Picks Long Ideas Short Ideas IPO Analysis US Market US Market Main Earnings Economy Housing ... Options Global Markets China India Japan Emerging Markets ... Oil ETFs ETF Main ETF Investment Guide ETF Selector Sectors Biotech Industrials Semis Energy ... Biotech Stocks Amgen and JNJ's Anemia Drug Showdown by: Mike Huckman posted on: March 12, 2008 AMGN JNJ Watchlist.add_to_favorite_article_symbols('amgn,jnj') Font Size: Print Email Ahead of the big Food and Drug Administration Advisory Committee meeting tomorrow, Amgen held a quick conference call with some reporters this afternoon. The outside panel of experts will be deciding whether to recommend putting more restrictions on the use of the blockbuster drugs used to fight anemia in cancer patients getting chemo. For Johnson and Johnson ( JNJ ) and especially Amgen ( AMGN ), the stakes are high. So, the biotech company gave reporters around 20-25 minutes to listen to and then question its head of research and development, Dr. Roger Perlmutter. But there was one small glitch: Dr. Perlmutter was calling in on a cell phone and at one point he apparently hit a dead zone and dropped out. Three to four minutes later, he reestablished contact. This left only enough time for by my count four reporters to ask questions. I don't know how many were listening in or in the queue. He didn't disclose his whereabouts. I'm assuming somewhere between Reagan National or Dulles and beautiful "downtown" Gaithersburg, Md., where the meeting is being held tomorrow.

64. IBMFS - Diamond-Blackfan Anemia DBA patients have only low red cell counts (anemia). The rest of their blood cells (the platelets and the white cells) are normal. ~25% of DBA patients have http://www.marrowfailure.cancer.gov/DBA.html

What are the IBMFS disorders? Amegakaryocytic Thrombocytopenia Diamond-Blackfan Anemia Dyskeratosis Congenita Fanconi Anemia Pearson Syndrome Severe Congenital Neutropenia ... Other Bone Marrow Failure Syndromes Diamond-Blackfan Anemia (DBA) DBA patients have only low red cell counts ( anemia ). The rest of their blood cells (the platelets and the white cells ) are normal. ~25% of DBA patients have physical abnormalities, often involving malformations of the thumbs. Most patients are diagnosed within the first year of life. Detecting a mutation in a known DBA gene confirms the diagnosis. However, failure to find a mutation in a DBA gene does not eliminate the diagnosis of DBA. This is because the genes which have been identified so far explain less than half of the disease occurrences. Currently, DBA is diagnosed by clinical findings after exclusion of other known causes of pure red cell anemia. Males and females are affected equally. What are the major findings on physical examination?

65. Anemia, Hemolytic Complications of hemolytic anemias include all the ill effects of sometimes profound anemia as well as (in the newborn) possible problems caused by jaundice http://www.drhull.com/EncyMaster/A/hemolytic_anemia.html

Help for sleepless parents Guaranteed Unlimited personal help Encyclopedia Index A anemia, hemolytic Search anemia, hemolytic The hemolytic anemias are those caused by destruction of red cells in the bloodstream by a disease process. They include hemolytic disease of the newborn, usually caused by blood group incompatibility between mother and baby ( ABO incompatibility Rh factor incompatibility hemolytic anemias caused by abnormal red cell membranes, chiefly hereditary spherocytosis and hereditary elliptocytosis, and a variety of other, rarer conditions hemolytic anemias caused by abnormal hemoglobin (the oxygen carrying molecule that fills the red cell); for example sickle cell anemia and thallassemia Complications of hemolytic anemias include all the ill effects of sometimes profound anemia as well as (in the newborn) possible problems caused by jaundice

66. Amgen's Anemia Drugs Ailing - Forbes.com Study raises questions about treatments from biotech maker and also J J. http://www.forbes.com/markets/2008/02/27/amgen-johnson-update-markets-equity-cx_

var displayedChannel = 'markets'; var displayedSection = ''; Home Business Tech Markets ... Reference OAS_AD('BigBanner'); OAS_AD(centBan); showHMenu(fdcchannel); E-Mail Print Request Reprints E-Mail Newsletters RSS Market Scan Amgen's Anemia Drugs Ailing Carl Gutierrez 02.27.08, 5:15 PM ET A new study said Amgen and According to the report in the Journal of the American Medical Association , patients who take Amgen (nasdaq: AMGN news people ) and (nyse: JNJ news people )'s anemia medicines have a 10% greater risk of death than those who do not. The report cited 20 years of trials. Amgen's position is more complicated. Anemia drugs Epogen and Aranesp generate half of the company's $4.1 billion of sales and concerns that these medicines actually harm patients have caused doctors to cuts prescribing them. The drugs are a synthetic version of a hormone that causes the body to produce red blood cells. Worries that these medicines actually harm patients when overused have caused doctors to limit prescriptions. Congress has investigated the company's pricing practices, and its shares are down 27.0% in the past year. The drugs problems spurred a cost-cutting effort by the company. (See:

67. Sickle Cell Anemia Sickle cell anemia national and international resources, clinics with genetic counselors and geneticists. http://www.kumc.edu/gec/support/sickle_c.html

Sickle Cell Anemia American Sickle Cell Anemia Association P.O. Box 1971, 10300 Carnegie Ave, Cleveland, OH 44106, Phone: 216.229.8600, Fax: 216.229.4500 URL: www.ascaa.org/ E-mail: ashc@cybernex.net Support Groups Online video Sickle Cell Disease Association of America, Inc. (SCDAA), formerly know as the National Association for Sickle Cell Disease (NASCD) 200 Corporate Pointe, Suite 495, Culver City California 90230-8727, Phone: 310.216.6363 or 800.421.8453, Fax: 310.215.3722, E-mail: scdaa@sicklecelldisease.org What is Sickle Cell Disease? Education materials on Alpha Thalassemia, Beta Thalassemia, Hemoglobin C Trait (AC), Sickle Cell Trait (AS), Hemoglobin E Trait (AE) Map of United States with links to state organizations Uriel Owens Chapter SCDAA, PO BOX 171371, 650 Minnesota Ave., 2nd Floor, Kansas City, KS 66117, 913.621.1713, owens@sicklecellkck.org Sickle Cell Disease Association of Piedmont , NC Sickle Cell Anemia Research Foundation (SCARF), 2625 Third Street, P.O. Box 206, Alexandria, Louisiana 71309, 877.722.7370, e-mail: scarf@sicklecelldisease.org Regional Organizations, Clinics, Groups

68. FDA Adds Black Box To Anemia Drugs - USATODAY.com Drug maker Amgen Inc. says regulators have added new warnings about risks of death and tumor growth to its blockbuster anemia drugs. http://www.usatoday.com/news/health/2008-03-07-fda-warnings_N.htm

OAS_listpos = "InvCount,PageCount,AdOps1,Top728x90,Zaplet1,FloatBottom,Bottom728x90,VerticalBanner,Poster3,PosterBig,Links1,Links2,CommentSpon"; usat.contentID='31130040.story'; var tagID='31130040';usat.contentType='news'; Cars Auto Financing Event Tickets Jobs ... Shopping Search How do I find it? Subscribe to paper Home News ... A Better Life OAS_AD("PosterBig"); OAS_AD("VerticalBanner"); FDA adds black box to anemia drugs Updated document.write(niceDate('3/7/2008 6:28 PM')); Comment Recommend E-mail Save Print swapContent('firstHeader','applyHeader'); var storyURL = "http://www.usatoday.com/news/health/2008-03-07-fda-warnings_N.htm"; var storyTitle = "FDA adds black box to anemia drugs"; The new warnings approved Friday by the Food and Drug Administration warn that the company's drugs increased death and accelerated tumor growth in patients with several types of cancer, including breast and cervical. Prior labeling added to the drugs in November warned of similar risks in other types of cancers. Labeling approved by FDA said risks occurred when doctors treated patients with elevated levels of the drugs, which stimulate red blood cell levels. The action by FDA and the drug makers comes less than a week before a meeting where government advisers are scheduled to review the risks of the blockbuster medications.

69. Health Blog : Keep Anemia Drugs For Cancer Patients -- With Limits An FDA advisory committee voted 131 this afternoon to recommend that anemia drugs sold by Amgen and Johnson Johnson still be available for cancer http://blogs.wsj.com/health/2008/03/13/keep-anemia-drugs-for-cancer-patients-wit

@import url(http://s.wsj.net/css/newwsj.css); @import url(http://s.wsj.net/css/j20type.css); var site="WSJ",pID="0_0002",nSP="http://online.wsj.com",gcPH="/pj/PortfolioDisplay.cgi",gcWIA="http://users.wsj.com/WebIntegration/WebIntegrationServlet",gcLFU="https://commerce.wsj.com/auth/submitlogin",gcHSP="https://",gcDomain="online.wsj.com",pStl="2-col",PSS="0_0002",PSSG="header0_0002" WSJ.com MarketWatch.com Barrons.com All Things Digital More BigCharts Virtual Stock Exchange WSJ Asia WSJ Europe ... WSJ Chinese SEARCH SEARCH User Name: Password: Remember Me Log In Forgot your username or password? WELCOME Log Out HEALTH BLOG Blog Search: Previous SEE ALL POSTS FROM THIS BLOG Next March 13, 2008, 3:11 pm Posted by Jacob Goldstein For about a year now, regulators have been looking into suggestions that the drugs, sold under the brand names Aranesp, Epogen and Procrit, might increase the risk of death Still, the FDA has said The panel also endorsed a proposal that Amgen has backed that would require an unusually stringent informed consent procedure for cancer patients who receive the drug. Update up nearly 5% today . In after-hours trading Amgen shares off a little. Permalink wsj:http://blogs.wsj.com/health/2008/03/13/keep-anemia-drugs-for-cancer-patients-with-limits/

70. Anemia Drug Can Kill Cancer Patients - Cancer - MSNBC.com Feb 26, 2008 Treating cancer patients with anemia drugs increases their risk of blood clots and death, US researchers said on Tuesday, http://www.msnbc.msn.com/id/23357376/

Skip navigation Web MSNBC Health Diet and nutrition Women's health Men's health ... Health library Categories U.S. news World news Politics Business ... Local news Browse Video Photos Community Today Show ... Meet the Press Anemia drug can kill cancer patients Risk of death increased by 10 percent, researchers found CHICAGO - Treating cancer patients with anemia drugs increases their risk of blood clots and death, U.S. researchers said on Tuesday, confirming concerns about these widely used drugs. Researchers said the drugs, erythropoiesis-stimulating agents or ESAs, raise the risk of death by 10 percent in patients who took them compared to those who did not, a finding that could not be explained by the higher blood clot risk alone. Anemia is a common complication of cancer treatment. “The findings of mortality are new and are different from prior reports,” said Dr. Charles Bennett of Northwestern University in Chicago, whose study appears in the Journal of the American Medical Association. He said the drugs also increased the risk of blood clots in the lungs and legs by 57 percent in cancer patients, confirming other findings. “Our findings, in conjunction with basic science studies, raise the concern that the drug may be stimulating cancer and shortening cancer patients’ survival,” Bennett said in a statement.

71. U.S. Advisers: Restrict Amgen, J&J Anemia Drugs | Reuters GAITHERSBURG, Maryland (Reuters) The widespread use of anemia drugs sold by Amgen Inc and Johnson Johnson should be sharply restricted for cancer http://www.reuters.com/article/businessNews/idUSN1330236820080313?feedType=RSS&f

72. Monkey Maddness - ANEMIA CAUSED BY ONIONS Article on onion toxicity in monkeys, dogs and cats. http://monkeymaddness.com/articles/onions.html

ANEMIA CAUSED BY ONIONS Written by Margaret A. Wissman (This article was in the Simian, the SSA's monthly newsletter, some time ago.) As a veterinarian, I have known for many years that onions, whether fresh, cooked or dehydrated, can cause anemia in pets. I remember reading a case report years ago concerning a small dog that ate a good portion of a bag of fresh, whole onions one day while his owner was at work, and the dog was near death when discovered by his frantic owner. However, I continually read stories (including one in the most recent Simian Society Newsletter) about owners feeding onions to their monkeys, and I realize that most people have no idea of the dangers of feeding onions. So, I thought it would be a good idea to educate owners about onions. Let's now cut through all this medical jargon. What exactly does happen when onions are consumed? Simply put, onions cause red blood cells to become unable to function properly, then causing them to rupture. This cause anemia. What clinical signs will occur with onion toxicosis? The signs that you see will depend on the amount of onions consumed, the length of time they have been fed, and the size of the animal. Gums (mucous membranes) may appear pale if there is moderate or severe anemia/ If lots of RBCs have ruptured, there may be hemoglobin in the urine, causing it to appear reddish or brown, or the tissues may become jaundiced. Weakness, depression, rapid heart rate and rapid respiratory rate may be observed as a result of there not being enough oxygen reaching the tissues (hypoxia). Vomiting, decreased appetite and diarrhea may also occur. Blood tests taken by your veterinarian will show certain characteristics. Heinz-bodies can be seen on blood smears and the packed cell volume will be decreased, indicating anemia. As the body tries to replace the damaged blood cells, certain characteristics may also be seen in the blood. Hemoglobin may be seen in the urine.

73. Sickle Cell Anemia - Case Study Collection - National Center For Case Study Teac Case Teaching Notes for Sickle Cell anemia, by Debra Stamper, Department of Biology, King s College. From the Case Study Collection of the National Center http://ublib.buffalo.edu/libraries/projects/cases/sickle_cell1.html

Sickle Cell Anemia Section 1: The Inquiry Begins by Debra Stamper Department of Biology King's College It was a brisk fall day in Bostonthe type of day that Dr. William Castle preferred to start with a cup of coffee while he caught up on his correspondence, which often appeared to be an endless task. As a faculty member of Harvard Medical School, he had always received a fair amount of inquiries, but after he had published his data indicating that pernicious anemia was due to a vitamin B12 deficiency, the amount of mail he received was sometimes overwhelming. Sitting in his reclining chair he sorted through the large pile that had accumulated. He began to meticulously segregate it into smaller piles he would open in a prescribed order. Usually the delegation of a particular envelope was a relatively easy choice. There were a few that caused him to pause for a moment, such as the one he was currently holding. The return address indicated it was from an Irving Sherman at Johns Hopkins University. Since it was from someone he had never heard of, he was inclined to place it in the pile to be opened later. But on this day he decided to take another sip of coffee and see what Mr. Sherman had to say. "Well, this may have some merit," Dr. Castle mused to himself. He recognized that these results indicated it was likely that there was a difference in one or more molecules found either in the blood or within the red blood cells. Since sickle cell anemia was named due to the change in the shape of the red blood cells, the molecule involved was most likely within the red blood cells. Dr. Castle placed the letter in a conspicuous place on his desk so that he would remember to send a reply to the ambitious student.

74. Anemia Guide Download This TealInfo folio is a guide to anemia in children and adults. After picking a class of anemia (microcytic, normocytic or macrocytic), you can choose a http://www.pdacortex.com/Anemia Guide_Download.htm

Anemia Guide TealInfo Developer: Vincent Iannelli This TealInfo folio is a guide to Anemia in children and adults. After picking a class of anemia (microcytic, normocytic or macrocytic), you can choose a type of anemia (for example, iron deficiency, thalesemia, chronic disease, lead poisoning, hemolysis, aplastic anemia, vitamin B12 or folate deficiency, etc) and see common lab values for that type of anemia and other details. IT's Cutting Edge

75. Diamond Blackfan Anemia And You Information on Diamond Blackfan anemia collected from various sources across the web and from those affected by DBA. http://www.diamondblackfananemia.com/

Diamond Blackfan Anemia and You (this site is under construction) Welcome to Diamond Blackfan Anemia and You ! This site is dedicated to helping educate people about this rare blood disorder and topics that are often associated with not only individuals with DBA, but their friends and families as well. I hope you find this site beneficial and if you ever find something you think should be posted here or if you see a mistake (everyone makes them), please let me know and it will I will take care of it as soon as possible. Also, Please be aware that this site uses links from various sources for information about DBA and related disorders. All sources are credited and any mention of a specific product, company, or organization, website, or URL address, does not imply a recommendation or endorsement by this site. This site is for informational and educational purposes only and is not intended to provide or be a substitute for professional medical advice, diagnosis, or treatment. Comments posted to this site reflect the ideas and opinions of those posting and not the website author.

76. The Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins Aplastic anemia (AA) is the medical term for bone marrow failure. Though not a cancer, the treatment of aplastic anemia is often similar to therapies http://www.hopkinskimmelcancercenter.org/cancertypes/aplastic-anemia.cfm?canceri

77. Thalassemia: Rochester Chapter: The Fight Against Thalassemia: Cooley's Anemia This site was created to provide information and awareness to the public about the inherited blood disorder called Thalassemia (Cooley s anemia). http://www.thalsite.com/

Home The Facts Support Group Patient Profiles ... Help Us LIVING WITH THALASSEMIA This site was created to inform people of an inherited blood disorder called Thalassemia Major, also known as Cooley's Anemia, and to bring patients and families together for support and education on Thalassemia. I was born with Thalassemia Major. My Father also had Thalassemia Major and my Mother has the Thalassemia trait. My Father passed away at the age of 48 from the complications of this fatal blood disorder. I am 33 years old and have been receiving transfusions every 4 weeks at Strong Memorial hospital since I was two. My hematocrit (blood count) usually is anywhere from 25-30 before transfusions. If my blood count is below 30 I receive 3 bags of washed packed red cells. If my blood count is 30 or above I receive 2 bags of washed packed red cells. A normal blood count for a woman is 35-40. For a male a blood count would be 40-45. Patients with Thalassemia Major require transfusions because of blood cells that contain little or no hemoglobin. Usually two normal parents that both have a Thalassemia trait will pass on this disorder to their children not knowing that they were both carriers of the Thalassemia trait. When two Thalassemia traits get together a child will inherit this blood disorder. I started this web-site to inform people and to make new friends. I have met so many wonderful people from this web-site. I thank you all for your kindness. Please feel free to sign the guestbook and let me know how I am doing. Thanks!

78. Aplastic Anemia - Lucile Packard Children's Hospital Information from LPCH, the leading children’s hospital in northern California, on aplastic anemia causes, symptoms, diagnosis, treatment and prevention. http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/hematology/aplsanem.html

Hematology Hematopoietic Stem Cell Transplantation Oncology Pediatric Bone Marrow Transplantation ... “Keep Saving Money for Emma’s College Fund!” Hematology and Blood Disorders Aplastic Anemia What is aplastic anemia? Aplastic anemia occurs when the bone marrow produces too few of all types of blood cells: red cells, white cells, and platelets. A reduced number of red blood cells causes the hemoglobin (a type of protein in the red blood cells that carries oxygen to the tissues of the body) to drop. A reduced number of white blood cells causes the patient to be susceptible to infection. A reduced number of platelets can cause the blood not to clot as easily. What causes aplastic anemia? Aplastic anemia in children has multiple causes. Some of these causes are idiopathic, meaning they occur sporadically for no known reason. Other causes are secondary, resulting from a previous illness or disorder. Nearly 50 to 75 percent of childhood cases of aplastic anemia occur sporadically for no known reason. Acquired causes, however, may include: history of specific infectious diseases such as hepatitis, Epstein-Barr virus (EBV), cytomegalovirus (CMV), parvovirus B19, or human immunodeficiency virus (HIV)

79. --- AA&MDSIF - AA --- Aplastic anemia occurs when the bone marrow stops making enough However, the disorder was not officially termed as aplastic anemia until 1904. http://www.aplastic.org/aplastic/disease_information/about_the_diseases/aplastic

Home About the Diseases Drug Information Educational Materials ... Information Packet Search Get the most current updates on your disease, drug information, clinical trials, medical research, and more. The Bone Marrow Failure Disease Consortium is sponsoring research studies around the country. more info... Fred Hutchinson Cancer Research Center to Hold Patient Conference on Marrow Failure Saturday June 7, 2008 more info... Text Size Printer-friendly page Home About the Diseases > Aplastic Anemia Aplastic Anemia Aplastic anemia occurs when the bone marrow stops making enough blood-forming stem cells History: The diseases can be traced back to 1888 when a famous German pathologist Dr. Paul Ehrlich studied the case of a pregnant woman who died of bone marrow failure. However, the disorder was not officially termed as "aplastic anemia" until 1904. Blood and bone marrow findings: Patients with aplastic anemia typically have low blood cell counts in all three blood lines - red blood cells white blood cells , and platelets . Upon examination, the bone marrow is found to be hypoplastic or aplastic , meaning low growth or no growth of blood-forming stem cells. Chromosomal abnormalities are not typically found in theses instances.

80. Sickle Cell Information Center Home Page Current information for health care providers, patients, the public, teachers and others with online treatment guideline books, a tutorial, multiple links http://www.scinfo.org/

The Mission of the Sickle Cell Information Center www.SCInfo.org The mission of this site is to provide sickle cell patient and professional education, news, research updates and world wide sickle cell resources. It is the mission of our organizations to provide world class compassionate care, education, counseling, and research for patients with sickle cell disease. It is our mission to help break the sickle cycle. "The information provided on this site is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician." This site maintains the privacy of all individuals and no information is gathered. This site is not supported by and does not accept advertising requests. Content and responses are reviewed by the Center Advisory Board How May We Serve You? What is Sickle Cell Disease? Health Care Providers Online Resources and Guidelines Patients and Families Online Resources World Wide Resources - Links, Contacts, and Clinics ... Streaming Videos Search WWW Search SCInfo.org

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