1. Dengue Fever Fact Sheet - CDC Division Of Vector-Borne Infectious Diseases (DVBI The Centers for Disease Control and Prevention presents detailed information about this mosquitoborn disease, including maps of distribution of the http://www.cdc.gov/NCIDOD/DVBID/DENGUE/

Dengue Contents Introduction Fact Sheet Images Slides ... Dengue Fever Information for Travelers Resources Related links Chikungunya Fever Fact Sheet History Current Trends ... Future Outlook Outbreak Notice! Update: Dengue, Tropical and Subtropical Regions For more information visit CDC's Travelers' site (http://wwwn.cdc.gov/travel/ contentDengueTropicalSubTropical.aspx) ... Dengue Brochure (PDF 138KB/2 pages) Materials for Puerto Rico (in Spanish) Letter for healthcare providers/ Carta para proveedores de salud (PDF 91KB/2 pages) Handout for patient education/ Folleto para pacientes (PDF 28KB/1 page) (PDF 119KB/2 pages) Dengue Fact Sheet in PDF (PDF 79KB/3 pages) Perspectives Dengue (DF) and dengue hemorrhagic fever (DHF) are caused by one of four closely related, but antigenically distinct, virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), of the genus Flavivirus . Infection with one of these serotypes provides immunity to only that serotype for life, so persons living in a dengue-endemic area can have more than one dengue infection during their lifetime. DF and DHF are primarily diseases of tropical and sub tropical areas, and the four different dengue serotypes are maintained in a cycle that involves humans and the

2. Dengue Fever - Wikipedia, The Free Encyclopedia dengue fever (IPA / d ge /) and dengue hemorrhagic fever (DHF) are acute febrile diseases, found in the tropics and Africa, with a geographical spread http://en.wikipedia.org/wiki/Dengue_fever

Dengue fever From Wikipedia, the free encyclopedia Jump to: navigation search "Dengue Fever" redirects here. For the band of the same name, see Dengue Fever (band) Dengue virus A TEM micrograph showing dengue virus Virus classification Group: Group IV (+)ssRNA Family: Flaviviridae Genus: Flavivirus Species: Dengue virus Dengue fever Classification and external resources ICD A ICD DiseasesDB ... MeSH Dengue fever IPA /ˈdɛŋgeɪ/ ) and dengue hemorrhagic fever (DHF) are acute febrile diseases , found in the tropics and Africa , and caused by four closely related virus serotypes of the genus Flavivirus , family Flaviviridae The geographical spread is similar to malaria , but unlike malaria, dengue is often found in urban areas of tropical nations, including Singapore Taiwan Indonesia Philippines ... India and Brazil . Each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. Dengue is transmitted to humans by the Aedes aegypti (rarely Aedes albopictus mosquito , which feeds during the day. Contents Signs and symptoms Diagnosis Treatment Emerging treatments ... edit Signs and symptoms This article or section is missing citations or needs footnotes Using inline citations (April 2008) This infectious disease is manifested by a sudden onset of fever , with severe headache, muscle and joint pains ( myalgias and arthralgias —severe pain gives it the name break-bone fever or bonecrusher disease ) and rashes . The dengue rash is characteristically bright red petechiae and usually appears first on the lower limbs and the chest; in some patients, it spreads to cover most of the body. There may also be

3. WHO | Dengue dengue is transmitted by the bite of an Aedes mosquito infected with any one of the four dengue viruses. It occurs in tropical and subtropical areas of the http://www.who.int/topics/dengue/en/

Language options Search Main navigation Home About WHO Countries Health topics ... Health topics Main content Dengue Dengue is transmitted by the bite of an Aedes mosquito infected with any one of the four dengue viruses. It occurs in tropical and sub-tropical areas of the world. Symptoms appear 3—14 days after the infective bite. Dengue fever is a febrile illness that affects infants, young children and adults. Symptoms range from a mild fever, to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash. There are no specific antiviral medicines for dengue. It is important to maintain hydration. Use of acetylsalicylic acid (e.g. aspirin) and non steroidal anti-inflammatory drugs (e.g. Ibuprofen) is not recommended. Dengue haemorrhagic fever (fever, abdominal pain, vomiting, bleeding) is a potentially lethal complication, affecting mainly children. Early clinical diagnosis and careful clinical management by experienced physicians and nurses increase survival of patients. RELATED SITES Dengue/dengue haemorrhagic fever DengueNet (WHO global dengue surveillance) Dengue (Region of the Americas - PAHO) Dengue and dengue haemorrhagic fever (South-East Asia Region) ... Dengue (Western Pacific Region) FACT SHEETS Dengue and dengue haemorrhagic fever PUBLICATIONS Publications: dengue RELATED LINKS Disease outbreaks: dengue fever Disease outbreaks: dengue haemorrhagic fever Dengue (Special Programme for Research and Training in Tropical Diseases, TDR)

4. Dengue Fever, NIAID, NIH Factsheet with cause, symptoms, diagnosis, treatment, and prevention. http://www.niaid.nih.gov/factsheets/dengue.htm

Search Advanced Search Help Site Index Contact Us ... News Releases Dengue Fever Overview Treatment Cause Prevention ... News Releases See Also NIAID Research on Viral Infections Dengue and hemorrhagic fever: A potential threat to public health in the United States Modified Skeeters Could Save People from Dengue Fever E-mail this page Print this page See Also NIAID Research on Viral Infections Dengue and hemorrhagic fever: A potential threat to public health in the United States Modified Skeeters Could Save People from Dengue Fever Home Help Site Index Accessibility ... Contact Us Last Updated January 8, 2008 National Institute of Allergy and Infectious Diseases (NIAID) National Institutes of Health (NIH) Department of Health and Human Services (HHS)

5. Dengue Fever Facts dengue DENghee is a flu-like viral disease spread by the bite of infected mosquitoes. dengue hemorrhagic fever is a severe, often fatal, complication of http://www.dhpe.org/infect/dengue.html

6. Chapter 4 - Dengue Fever - Yellow Book | CDC Travelers' Health dengue fever and dengue hemorrhagic fever (DHF) are viral diseases transmitted by Aedes mosquitoes, usually Aedes aegypti. The four dengue viruses (DEN1 http://wwwn.cdc.gov/travel/yellowBookCh4-DengueFever.aspx

@import url('http://www.cdc.gov/css/global.css'); @import url('/travel/css.ashx?s=2'); @import url('/travel/css.ashx?s=1'); Welcome to the CDC Travelers' Health site. Skip directly to the search box site navigation , or content Primary Navigation for the CDC Website Home About CDC Press Room A-Z Index ... Contact Us Department of Health and Human Services Centers for Disease Control and Prevention CDC en Espa±ol Search: Go Button: Travelers' Health: Yellow Book CDC Health Information for International Travel 2008 Email this page Printer-friendly version Yellow Book Home Search Contents Maps ... Yellow Book Chapter 4 Prevention of Specific Infectious Diseases Previous - Chapter 4 : Cyclosporiasis Next - Chapter 4 : Diphtheria Dengue Fever Description Dengue fever and dengue hemorrhagic fever (DHF) are viral diseases transmitted by Aedes mosquitoes, usually Aedes aegypti . The four dengue viruses (DEN-1 through DEN-4) are immunologically related, but do not provide cross-protective immunity against each other. Occurrence MAP 4-01 Areas of dengue fever cases reported in 2005, Western Hemisphere. Note: Due to limited surveillance in some countries, risk of dengue fever may exist in areas where no dengue fever cases have been reported.

7. Dengue Fever Causes, Signs, Symptoms, Treatment, Prevention And Facts On Medicin Get the facts on dengue fever causes (virus transmitted by infected mosquito), symptoms, signs, treatment, statistics and information on dengue hemorrhagic http://www.medicinenet.com/dengue_fever/article.htm

About Us Site Map May 28, 2008 home infectious disease center infectious disease a-z list dengue fever index > dengue fever article Font Size A A A Dengue Fever Index ... Glossary Dengue Fever Medical Author: John P. Cunha, DO Medical Editor: What is dengue fever? What areas are at high risk for contracting dengue fever? How is dengue contracted? What are the signs and symptoms of dengue? ... How can dengue fever be prevented? What is dengue fever? Dengue fever is a disease caused by a family of viruses that are transmitted by mosquitoes. It is an acute illness of sudden onset that usually follows a benign course with headache fever , exhaustion, severe joint and muscle pain , swollen glands ( lymphadenopathy ), and rash . The presence (the "dengue triad") of fever, rash, and headache (and other pains) is particularly characteristic of dengue. Dengue (pronounced DENG-gay) strikes people with low levels of immunity. Because it is caused by one of four serotypes of virus, it is possible to get dengue fever multiple times. However, an attack of dengue produces immunity for a lifetime to that particular serotype to which the patient was exposed. Dengue goes by other names, including "breakbone" or "dandy fever." Victims of dengue often have contortions due to the intense joint and muscle pain, hence the name breakbone fever. Slaves in the West Indies who contracted dengue were said to have dandy fever because of their postures and gait.

8. MedlinePlus: Dengue dengue is an infectious disease caused by a virus. You can get it if an infected mosquito bites you. It is common in warm, wet areas of the world. http://www.nlm.nih.gov/medlineplus/dengue.html

imageNames = false; @import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); @import url(http://www.nlm.nih.gov/medlineplus/images/header.css); @import url(http://www.nlm.nih.gov/medlineplus/images/menubutton.css); Skip navigation @import url("http://www.nlm.nih.gov/medlineplus/images/consumer_health_20.css"); Other Health Topics: A B C D ... List of All Topics Related Topics Hemorrhagic Fevers Infections Go Local Services and providers for Dengue in the U.S. Select Location AL - Alabama AR - Arkansas AZ - Arizona AZ - Tribal Connections Four Corners CO - Tribal Connections Four Corners DE - Delaware GA - Georgia IA - Iowa IL - Illinois IN - Indiana MA - Massachusetts MD - Maryland MI - Michigan MN - Minnesota NC - North Carolina NE - Nebraska NM - New Mexico NM - Tribal Connections Four Corners NV - Nevada OH - Ohio - Southeast SC - South Carolina TX - Central Texas TX - East Texas TX - South Texas TX - Texas Gulf Coast UT - Tribal Connections Four Corners UT - Utah VT - Vermont WY - Wyoming Select from map National Institutes of Health The primary NIH organization for research on Dengue is the National Institute of Allergy and Infectious Diseases Dengue Also called: Break-bone fever, Dengue fever

9. MySpace.com - Dengue Fever - LOS ANGELES, CALIFORNIA - Alternative / Indie - Www MySpace music profile for dengue Fever with tour dates, songs, videos, pictures, blogs, band information, downloads and more. http://www.myspace.com/denguefevermusic

var disableMSPLinks=1; Advertiser.SDC.DisplayedFriendEUD = "::0:0:ZGFhYjU4ZTFlZTAyZDhmZTXiFYVCMk16QEjit-sZHPI3WZr8eBOfCSdMaTSAH7R8FEwOkkgUo2FADNNxEQsxoGZq3qGScjscKXc4S2MtqkZLT0fiCznJ-P7RODC4BXf5"; sdc_wrapper("tkn_leaderboardband", "/Music/UserBandProfile,11021002", "Frame1"); User Shortcuts: Send Message Forward to Friend Add to Friends Add to Favorites Block User Add to Group Rank User Instant Message View User Pics View User Bulletins People MySpace Web Music Video Home Browse Search Invite ... Artist Signup Dengue Fever Alternative / Indie "Venus On Earth / In-Stores Now!" LOS ANGELES, CALIFORNIA United States Profile Views: 509695 Last Login: 5/28/2008 View My: Pics Videos Contacting Dengue Fever MySpace URL: http://www.myspace.com/denguefevermusic Dengue Fever: General Info Member Since Band Website denguefevermusic.com/ Band Members Chhom Nimol/Vocalist Zac Holtzman/Guitar/Vocals Ethan Holtzman/Farfisa organ Senon Williams/Bass Guitar David Ralicke/Brass Paul Smith/Drums Influences Sin Sisamouth Ros Sereysothea The Ventures Charles Mingus Blondie Funkadelic Os Mutantes Sounds Like A Cambodian Pop Rock Psychedelic dance party!

10. EMedicine - Dengue Fever : Article By Daniel D Price dengue has been called the most important mosquitotransmitted viral disease in terms of morbidity and mortality. dengue. http://www.emedicine.com/emerg/topic124.htm

Home Specialties Reference Centers All Sources eMedicine Medscape Drug Reference MEDLINE var jsRCName = ''; var jsRCPage = ''; Quick Find Introduction Clinical Differentials Workup ... References Related Articles Hepatitis Malaria Meningitis Pediatrics, Bacteremia and Sepsis ... Yellow Fever Patient Education Click here for patient education. Email to a colleague You are in: eMedicine Specialties Emergency Medicine INFECTIOUS DISEASES Dengue Fever Article Last Updated: Jan 31, 2008 AUTHOR AND EDITOR INFORMATION Section 1 of 11 Authors and Editors Introduction Clinical Differentials ... Author: Daniel D Price, MD, Director of Ultrasound Fellowship, Department of Emergency Medicine, Highland General Hospital, Alameda County Medical Center Daniel D Price is a member of the following medical societies: American College of Emergency Physicians and Society for Academic Emergency Medicine Coauthor(s): Sharon R Wilson, MD , Assistant Professor of Emergency Medicine, Department of Emergency Medicine, University of California at Davis Medical Center Editors: William K Chiang, MD

11. Dengue 2007 Number of Reported Cases of dengue and dengue Hemorrhagic Fever (DHF), Region of the Americas (by country and subregion) http://www.paho.org/English/ad/dpc/cd/dengue.htm

The Pan American Health Organization Promoting Health in the Americas Search Home Page Health Data Topics List Media Center Information Products PAHO Publishing Knowledge Resources Communicable Diseases Acute Respiratory Infections Anthrax Antimicrobial Resistance ... Hantavirus Influenza Avian Pandemic Seasonal International Health Regulations ... General Info/Links What's New CE142/17 - Dengue: Progress Report 2008: Number of Reported Cases of Dengue and Dengue Hemorrhagic Fever (DHF), Region of the Americas (by country and subregion) ... more items. Surveillance Featured Surveillance Items EID Updates: Emerging and Reemerging Infectious Diseases, Region of the Americas, Vol. 5, No. 9 (26 March 2008) This issue provides information on the increase in dengue and dengue hemorrhagic cases in several Brazilian states, focusing on Rio de Janeiro and on current measures being taken to fight the disease. eid-eer-2008-03-26.htm EID Updates: Emerging and Reemerging Infectious Diseases, Region of the Americas, Vol. 5, No. 8 (21 March 2008) This issue reports on how the Ministry of Health has created a crisis office to deal with the escalation in the number of dengue cases in Rio de Janeiro.

12. World Community Grid - Research - Discovering Dengue Drugs – Together Information about this project is provided on the web pages below and by the project scientists on the Discovering dengue Drugs Together website. http://www.worldcommunitygrid.org/projects_showcase/dddt/viewDddtMain.do

member name: password: writeForm("loginForm","/j_security_check","post"); forgot member name? forgot password? remember me: Select Language English Fran§ais Active Research Overview Nutritious Rice for the World Help Conquer Cancer AfricanClimate@Home Discovering Dengue About the Project Research Participants Project FAQs Human Proteome Folding - Phase 2 FightAIDS@Home Inactive Research Help Cure Muscular Dystrophy Completed Research Overview Genome Comparison Help Defeat Cancer Human Proteome Folding Project Status and Findings: Information about this project is provided on the web pages below and by the project scientists on the . For the latest status report, please go to the . If you have comments or questions about this project, please visit the Mission Significance Approach Dr. Stan Watowich and his research team at The University of Texas Medical Branch (Galveston, Texas, USA) have made significant progress in this direction, having discovered compounds that inhibit dengue and West Nile virus proteases and prevent virus replication in cell culture. However, additional drug candidates need to be discovered to improve the likelihood of converting drug leads into approved drugs for treating flavivirus infections. Return to Top World Community Grid's Advisory Board is looking for new research projects that can benefit from grid technology and have a positive impact on humanity.

13. Pediatric Dengue Vaccine Initiative The Pediatric dengue Vaccine Initiative (PDVI) is embarked on a quest to accelerate the development, evaluation, and introduction of vaccines that will help http://www.pdvi.org/

14. DENGUE Brief discription of dengue Fever, what it is, how do you get it, is there a cure? http://sped2work.tripod.com/dengue.html

Dengue Aedes aegypti, the mosquito that spreads Dengue fever. © 1995 L. E. Munstermann. Dengue occurs in most tropical areas of the world. Most U.S. cases occur in travelers returning from abroad, but the Dengue risk is increasing for persons living along the Texas-Mexico border and in other parts of the southern United States. There is no specific treatment for Dengue. Prevention centers on avoiding mosquito bites in areas where Dengue occurs or might occur and eliminating breeding sites. What is Dengue fever? What is Dengue hemorrhagic fever? Dengue fever is a flu-like illness spread by the bite of an infected mosquito. Dengue hemorrhagic fever is a severe, often fatal, complication of Dengue fever. What is the infectious agent that causes Dengue? Dengue and Dengue hemorrhagic fever are caused by any of the Dengue family of viruses. Infection with one virus does not protect a person against infection with another. How is Dengue spread? Dengue is spread by the bite of an Aedes mosquito. The mosquito transmits the disease by biting an infected person and then biting someone else. Where is Dengue found?

15. Dengue Fever Seeks 'Venus On Earth' : NPR Music But for my money, dengue Fever really hit their stride when they rock out and let Nimol lay into quirky, melodramatic Khmer melodies. http://www.npr.org/templates/story/story.php?storyId=87884427

16. ENN: Asia Shows Way To Fight Dengue As Global Spread Looms HONG KONG (Reuters) Clarissa Poon was one of an estimated 50 million people who contracted mosquito-borne dengue fever last year. http://www.enn.com/health/article/32742

/health/article/32742 /health/article/32742 Commentary A Happy Relationship Keeps Blood Pressure Low ENN: Environmental News Network TOP STORIES WILDLIFE ... Health Sign Up for Free NewsLetter Email Address Turn Your Desktop Green Download EcoWidget Stay updated with the ENN RSS feed PARTNERS Editorial Affiliates Press Members Recommended Sites Press Member Program ... Editorial Affiliate Program ADVERTISE WITH ENN Editorial Calendar Advertising Rates ENN ARCHIVES News Archive ABOUT ENN Letter from the CEO History Editorial Philosophy Staff ... Contact ENN Featured Affiliate Global Warming is Real View all the featured contributing content by this source /health/article/32742 Psoriasis symptoms This site covers psoriasis symptoms, psoriasis causes and psoriasis treatments. Printer Friendly Version Email to a Friend Close digg_url = 'http://www.enn.com/health/article/32742'; reddit_url = 'http://www.enn.com/health/article/32742'; //digg_bgcolor = '#ff9900'; //digg_skin = 'compact'; digg_window = 'new'; From: Reuters Published March 12, 2008 07:58 AM

17. Dengue History The first cases of dengue Fever (DF) were recorded in 1779 in Batavia, Indonesia, and Cairo. In 1780, there was an epidemic reported in Philadelphia, PA. http://justice.loyola.edu/~klc/BL472/Dengue/Dengue.history.html

HISTORY The first cases of Dengue Fever (DF) were recorded in 1779 in Batavia, Indonesia, and Cairo. In 1780, there was an epidemic reported in Philadelphia, PA. For the past 200 years, pandemics have been recorded in tropical and subtropical climates at 10 to 30 year intervals. In 1944, Albert Sabin successfully isolated the virus that causes DF and found that it belongs to the Flavivirdae virus family. There are more than 70 known members of the Flavividae family. Some examples include Yellow Fever and Japanese Encephalitis Virus (3). Flavivirdae are viruses that utilize humans, lower primates, and mosquitoes as hosts. The dengue virus relies on the mosquito Aedes aegypti as a vector to transmit it to human and primate hosts. Because dengue is thus an arthropod-borne virus, it is also classified as an arbovirus . The A. aegypti mosquito is an urban mosquito that thrives in pools of standing water. Peak transmission is associated with increased amounts of rainfall and mosquito density (3). Therefore, tropical climates are ideal for the mosquito to survive. Pools, puddles, buckets of water, gutters, and people spending a significant amount of time outdoors aid in successful transmission of the virus. Presently, there are four known serotypes of dengue virus. These are labeled DEN-1, DEN-2, DEN-3, and DEN-4. The different serotypes have the same morphology and genome; however, each serotype displays different antigens. Historically, DEN-2 is the prevalent serotype found in Southeast Asia and may be responsible to immunity against Yellow Fever. DEN-3 has been found in the Caribbean and DEN-1 has been found in the Pacific Islands (Hawaii, Marshall Islands).

18. Dengue dengue is a mosquitotransmitted acute disease caused by any of four virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4) and characterized by the sudden onset http://www.intmed.mcw.edu/ITC/Dengue92.html

Medical College of Wisconsin International Travelers Clinic Dengue Imported Dengue - United States, 1992 Morbidity and Mortality Weekly Report (MMWR), vol. 43, no. 6, Feb 18, 1994. Dengue is a mosquito-transmitted acute disease caused by any of four virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4) and characterized by the sudden onset of fever, headache, myalgia, rash, nausea, and vomiting. The disease is endemic in most tropical areas of the world and can occur in U.S. residents returning from international travel. Serum samples from 68 persons with suspected imported dengue with onset in 1992 (1) were submitted to CDC from 23 states (Table 1). Of these, 17 (25%) cases (from 10 states) were serologically or virologically diagnosed as dengue. This report summarizes information about these 17 cases. Nine of the 17 persons with laboratory-diagnosed dengue were females. Age was reported for 15 and ranged from 9-54 years (median: 34 years). Dengue serotype was identified by virus isolation for only one of the 17 cases as DEN-1. Travel histories were available for 14 persons with laboratory-diagnosed dengue (Table 1); infections were acquired in Asia (seven cases), the Caribbean Islands (five cases), Honduras (one), andColombia (one). The most commonly reported symptoms were consistent with classic dengue fever (e.g., fever, headache, myalgia, and rash). At least two persons required hospitalization; four patients developed a petechial rash; five had low white blood cell counts (1100-2500 per cubic millimeter [normal: 3200-9800 per cubic millimeter]); five had low platelet counts (42,000-77,000 per cubic millimeter [normal: 150,000-450,000 per cubic millimeter]); four developed elevated liver function test results, and one patient showed hemoconcentration (hematocrit: 51%).

19. Dengue Fever - Travel Medicine For The Adventure Traveler By Alan Spira, M.D. , dengue Fever is a viral infection common throughout the tropical regions of the world. It is spread by Aedes mosquitoes. http://www.armchair.com/info/spira7.html

Info Escapes Air Hotels ... Don't risk your health. Protect yourself from mosquito bites. For instant quotes and online policy issue of major medical insurance from the agents at Armchair World, please click here. Dengue Fever by Somewhere in Tanzania, maybe it was in Uganda, a lucky mosquito found its prey, zoomed in on its target and stole some blood from an unlucky human. This bite began innocently enough - happening during the day, not causing much of an itch - but several days later it lost all pretense of innocence. Lethargy, an unusual amount of tiredness, was the first sign that something was going awry. It was soon followed by a headache behind the eyes that throbbed and pounded, with a sensation of pressure like a kettle brewing and boiling. A fever, mild at first, but later intense with sweating, came bundled with ferocious muscle aches. These aches were rooted deep in the calves and back, and felt like being punched from the inside-out. The once-dinner-for-a-stray mosquito became apathetic and lost all appetite. What on earth could this be? Malaria? Typhoid? What, what, what? A funny pink rash showed up soon after. It didn't itch, it didn't bleed, it didn't hurt. It just spread - over the chest, belly, and back. It, along with the fever, lightened after two days but just two days later returned with even greater dramatic force. Ah, I think we have enough clues and a diagnosis now...

20. Discovering Dengue Drug-Together : Project Summary The mission of this project is to identify drug leads with broad spectrum activity against the related dengue, hepatitis C, West Nile, and yellow fever http://www.utmb.edu/discoveringdenguedrugs-together/

Discovering Dengue Drugs-Together Home Diseases Team Student Writings ... Contact s Project Summary The mission of this project is to identify drug leads with broad spectrum activity against the related dengue, hepatitis C, West Nile, and yellow fever viruses. The extensive computing power of World Community Grid will be used to complete the structure-based drug discovery calculations required to identify promising drug leads. Viruses from the family Flaviviridae , such as dengue (DENV), hepatitis C (HCV), West Nile (WNV), and yellow fever (YFV) viruses, pose significant health threats throughout the developed and developing world. More than 40% of the world’s population is at risk for infection by DENV. Annually, 1.5 million people are treated for dengue fever and dengue hemorrhagic fever. In addition, ~2% of the world’s population is infected with HCV. Yellow fever and West Nile viruses have also had significant global impact. Unfortunately, there are no drugs that effectively treat these diseases. One promising approach to combat these diseases is to develop drugs that inhibit the viral protease. This enzyme is critical for virus replication and is highly conserved among different flaviviruses.

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