1. Scleroderma Foundation - Home Page The scleroderma Foundation is a national nonprofit health organization dedicated to a threefold mission of Support, Education, and Research to help fight http://www.scleroderma.org/

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2. Scleroderma - Wikipedia, The Free Encyclopedia scleroderma is a chronic disease characterized by excessive deposits of collagen in the skin or other organs. The localized type of the disease, http://en.wikipedia.org/wiki/Scleroderma

Scleroderma From Wikipedia, the free encyclopedia Jump to: navigation search This article is about the disease. For the mushroom, see Scleroderma (genus) Systemic sclerosis Classification and external resources ICD M ICD OMIM ... MeSH Scleroderma is a chronic disease characterized by excessive deposits of collagen in the skin or other organs. The localized type of the disease, while disabling, tends not to be fatal. The systemic type or systemic sclerosis , the generalized type of the disease, can be fatal as a result of heart kidney lung or intestinal damage autoimmune disease Contents Signs and symptoms Skin symptoms Other organs Diagnosis ... edit Signs and symptoms edit Skin symptoms Scleroderma affects the skin , and in more serious cases it can affect the blood vessels and internal organs. The most evident symptom is usually the hardening of the skin and associated scarring. The skin may appear tight, reddish or scaly. Blood vessels may also be more visible. Where large areas are affected, fat and muscle wastage may weaken limbs and affect appearance. The seriousness of the disease varies hugely between cases. The two most important factors to consider are the level of internal involvement (beneath the skin) and the total area covered by the disease. In general, the more skin that is involved, the more severe the case of scleroderma.

3. Scleroderma Symptoms, Causes, Treatment, Prognosis And Diagnosis On MedicineNet. Read about treatment of scleroderma. scleroderma is a chronic condition that causes inflammation and thickening of the skin. The cause of scleroderma is not http://www.medicinenet.com/scleroderma/article.htm

About Us Site Map May 29, 2008 home arthritis center arthritis a-z list scleroderma index > scleroderma article Font Size A A A Scleroderma Index ... Glossary Scleroderma Medical Author: William C. Shiel Jr., MD, FACP, FACR What is scleroderma? How is scleroderma classified? What are symptoms of scleroderma? ... Scleroderma At A Glance Scleroderma Elbow Tip Pains Medical Author: William C. Shiel Jr., MD, FACP, FACR Scleroderma is a chronic condition that causes inflammation and thickening of the skin. The cause of scleroderma is not known. Researchers have found some evidence that genes are important factors, but the environment seems to also play a role. This means that inheritance at least play a partial role. It is not unusual to find other autoimmune diseases in families of scleroderma patients. Some evidence for the role genes may play in leading to the development of scleroderma comes from the study of Choctaw Native Americans who are the group with the highest reported prevalence of the disease. The disease is more frequent in females than in males. A common area of involvement of this condition is the skin over the tips of the elbows (the olecranon area). When this skin is involved, it can lead to troublesome irritation of the tips of the elbows with tenderness noted when any pressure is applied.

4. MedlinePlus: Scleroderma scleroderma means hard skin. It is a group of diseases that causes abnormal growth of connective tissue, the proteins that support your skin and organs. http://www.nlm.nih.gov/medlineplus/scleroderma.html

imageNames = false; @import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); @import url(http://www.nlm.nih.gov/medlineplus/images/header.css); @import url(http://www.nlm.nih.gov/medlineplus/images/menubutton.css); Skip navigation @import url("http://www.nlm.nih.gov/medlineplus/images/consumer_health_20.css"); Other Health Topics: A B C D ... List of All Topics Related Topics Raynaud's Disease Immune System Skin, Hair and Nails Go Local Services and providers for Scleroderma in the U.S. Select Location AL - Alabama AR - Arkansas AZ - Arizona AZ - Tribal Connections Four Corners CO - Tribal Connections Four Corners DE - Delaware GA - Georgia IA - Iowa IL - Illinois IN - Indiana MA - Massachusetts MD - Maryland MI - Michigan MN - Minnesota NC - North Carolina NE - Nebraska NM - New Mexico NM - Tribal Connections Four Corners NV - Nevada OH - Ohio - Southeast SC - South Carolina TX - Central Texas TX - East Texas TX - South Texas TX - Texas Gulf Coast UT - Tribal Connections Four Corners UT - Utah VT - Vermont WY - Wyoming Select from map National Institutes of Health The primary NIH organization for research on Scleroderma is the National Institute of Arthritis and Musculoskeletal and Skin Diseases Scleroderma Also called: Circumscribed scleroderma, Dermatosclerosis, Morphea, Systemic sclerosis

5. Scleroderma - MayoClinic.com scleroderma — Comprehensive overview covers symptoms and treatment of this disease that involves skin thickening. http://www.mayoclinic.com/health/scleroderma/DS00362

Medical Services Health Information Appointments Education and Research ... About Scleroderma ARTICLE SECTIONS Introduction Signs and symptoms Causes When to seek medical advice ... Coping skills Introduction In some cases, scleroderma also affects the blood vessels and internal organs. Scleroderma is one of a group of arthritic conditions called connective tissue disorders. In these disorders, a person's antibodies are directed against his or her own tissues. Researchers haven't established a definitive cause for scleroderma. It's more common in women than in men and more common in adults than in children. Scleroderma can run in families, but in most cases it occurs without any known family tendency for the disease. Scleroderma isn't considered contagious or cancerous, but this chronic condition can greatly affect self-esteem and the ability to accomplish everyday tasks. NEXT: Signs and symptoms ARTICLE TOOLS Print this section All sections E-mail this Larger type Reprints and permissions By Mayo Clinic Staff Oct 19, 2006 About this site Site help Contact us e-Newsletter ... Reprints and permissions updated Feb 8, 2008

6. Handout On Health: Scleroderma This booklet is for people who have scleroderma, as well as for their family members, friends, and others who want to find out more about the disease. http://www.niams.nih.gov/Health_Info/Scleroderma/default.asp

Skip main navigation and go to sub navigation menu. Skip main navigation and go to main content of page. Skip main navigation and go to related information. Home ... Print Friendly Page You are here: Health Information Related Information What is Scleroderma? (fast facts, easy-to-read) Scleroderma: Summaries of Research Other Information Rheumatic Disease Order a NIAMS Publication to be mailed Scleroderma Find a Clinical Trial ... Journal Articles Scleroderma PDF Version of this Document Order this publication Publication Date: May 2001 Revised July 2006 Handout on Health: Scleroderma This booklet is for people who have scleroderma, as well as for their family members, friends, and others who want to find out more about the disease. This booklet describes the different forms of scleroderma and provides information on their symptoms, diagnosis, and treatment, including what patients can do to help manage their disease and the problems associated with it. This booklet also highlights current research efforts into the understanding and treatment of scleroderma, many of which are supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and other components of the Department of Health and Human Services' National Institutes of Health (NIH). If you have further questions after reading this booklet, you may wish to discuss them with your doctor. What Is Scleroderma?

7. EMedicine - Scleroderma : Article By Sergio Jimenez scleroderma is derived from the Greek words skleros (hard or indurated) and derma (skin). Hippocrates first described th. http://www.emedicine.com/MED/topic2076.htm

Home Specialties Reference Centers All Sources eMedicine Medscape Drug Reference MEDLINE var jsRCName = ''; var jsRCPage = ''; Quick Find Introduction Clinical Differentials Workup ... References Related Articles Eosinophilia Eosinophilia-Myalgia Syndrome Eosinophilic Fasciitis Graft Versus Host Disease ... Scleroderma Patient Education Click here for patient education. Email to a colleague You are in: eMedicine Specialties Rheumatology Systemic Rheumatic Disease Scleroderma Article Last Updated: Aug 15, 2007 AUTHOR AND EDITOR INFORMATION Section 1 of 11 Authors and Editors Introduction Clinical Differentials ... Author: Sergio A Jimenez, MD , Dorrance H Hamilton Professor, Department of Medicine, Director, Division of Rheumatology, Thomas Jefferson University Sergio Jimenez is a member of the following medical societies: American College of Physicians American College of Rheumatology , and Society for Investigative Dermatology Coauthor(s): Patrick M Cronin, DO, FACR, Clinical Associate Professsor of Medicine, Department of Medicine, Division of Rheumatology, University of Pennsylvania Health System, Pennsylvania Hospital; Andrew Koenig Marie Spevak O'Brien, DO

8. Patient Education - Scleroderma scleroderma, also known as systemic sclerosis, is a chronic disease that causes skin thickening and tightening, and can involve fibrosis and other types of http://www.rheumatology.org/public/factsheets/scler_new.asp

View Site Map ACR Home Patient Education Printer-friendly Format SCLERODERMA (Systemic Sclerosis) Scleroderma, also known as systemic sclerosis, is a chronic disease that causes skin thickening and tightening, and can involve fibrosis and other types of damage to internal body organs. This condition, thought to be an autoimmune disease, affects both adults and children, most commonly adult women. While effective treatments are available for some manifestations of the disease, scleroderma is not yet curable. What it is Broader health impacts What causes it Living with scleroderma ... For more information Fast Facts Scleroderma is a relatively uncommon problem affecting only 200 to 300 people per million in the U.S. Some 12 to 20 new cases per million are diagnosed annually. Although the underlying cause of scleroderma is not known, promising research is shedding new light on the relationship between the immune system and scleroderma. Medicines traditionally used to treat other autoimmune diseases – such as rheumatoid arthritis and lupus – often have little effect on scleroderma.

9. Hardin MD : Scleroderma From the University of Iowa, the *best* lists of Internet sources in scleroderma. http://www.lib.uiowa.edu/hardin/md/scleroderma.html

Scleroderma Return to Hardin MD : Home Medical Pictures People interested in this subject often clicked these ... Autoimmune Diseases Dermatitis Herpetiformis Dermatomyositis Fibromyalgia ... Scleroderma Symptoms MEDLINE plus Scleroderma Google Directory : Scleroderma National Women's Health Information Center : Scleroderma Wikipedia : Scleroderma Yahoo Directory : Scleroderma Scleroderma Symptoms Scleroderma symptoms for systemic sclerosis International Scleroderma Network, Edina, Minnesota Scleroderma symptoms Univ Maryland / A.D.A.M. Mayo clinic, Rochester, Minnesota Scleroderma symptoms ADAM Health Encyclopedia, NLM MEDLINEplus Hardin Library for the Health Sciences , University of Iowa Please send comments to hardin-webmaster@uiowa.edu The URL for this page is http://www.lib.uiowa.edu/hardin/md/scleroderma.html Last updated Thursday, Aug 30, 2007 [scleraderma, pictures of scleroderma, morphea disease, sclaraderma, symptoms of scleroderma, schleroderma, scleroderma symtoms, scleroderma symptons, sclerederma, picture of the disease scleroderma, picture of scleroderma skin, disease scleroderma picture, early symptoms of scleroderma, information on scleroderma, scleroderma images, scleroderma photos, scleroderma pics, fotos, scleroderma photographs][293663

10. International Scleroderma Network The nonprofit International scleroderma Network presents stellar research, support, education and awareness for scleroderma and related autoimmune and http://www.sclero.org/

ISN Home Support Forums Translations ... Contact ANY match ALL words EXACT Help Mobile Device Users: Skip to Page Content The #1 scleroderma site with 2,000+ pages in 22 languages: Arabic Chinese Deutsche/German English ... Worldwide Lists Scoring for Scleroderma! Lisa Bulman's 3rd Annual Scoring for Scleroderma Soccer Tournament will be held Friday evening, June 20, 2008, at the Canton Sportsplex in Canton, Massachusetts! (Also see: Lisa Bulman Event Donation and Player Registration Posted 05-20-08. MAIN SITE MENU Home (Main) Donations ISN Profiles Translations ... Support Groups Thanks to Actelion Find Scleroderma Experts! Scleroderma Experts (Worldwide Listings) Tackle Scleroderma: Join/Shop/Donate! Awareness Bracelets! Only $2.50 each! In Honor Of: Delores Gumino Mya Manns In Loving Memory Of: Judy D'Aquino Sharon Rose Barringer Sherrill Knaggs Maxine Gail Mackler Janine Wozniak Donate in Memory (Others) Last 12 Donors Include: Diane Dube Gene and Shelley Ensz Chris Sonetz Amy Narot Patti Kyle James Scalise David Gumino Tina Gibbons Paul Sandilla Chris Palermo Frank Miller Amanda Nadolski More Donors...

11. Scleroderma Raynaud s phenomenon is often the first sign of the scleroderma disease process. With this condition, small blood vessels narrow in the fingers, toes, ears, http://www.umm.edu/patiented/articles/what_symptoms_of_scleroderma_000088_2.htm

Information Referring Physicians Health Care Professionals Job Seekers ... References Services at the UM Medical Center See a complete list of Specialty Services and Departments at UMMC. Scleroderma Description An in-depth report on the causes, diagnosis, treatment, and prevention of scleroderma. Alternative Names Systemic sclerosis Symptoms Raynaud's Phenomenon Raynaud's phenomenon is often the first sign of the scleroderma disease process. With this condition, small blood vessels narrow in the fingers, toes, ears, and even the nose. Typically, the fingers go through three color changes: First, they become very pale. As the blood flow is cut off, they turn a bluish color, usually in the top two sections of the second and third fingers. Finally, when blood flow returns, the fingers become red. Tingling and pain may occur in the affected regions. Click the icon to see an image of Raynaud's phenomenon. Attacks of Raynaud's phenomenon can occur several times a day, and are often brought on or made worse by cold. Warmth relieves these attacks. In severe cases, attacks may develop regardless of the temperature. Severe cases may also cause open sores or damage to the skin and bones, if the circulation is cut off for too long. The syndrome may also be triggered by stress. It is important to note that over 80% of cases of Raynaud's phenomenon are harmless. It is very common and occurs in 3 - 5% of the general population. This condition is more likely to be a symptom of scleroderma or some other connective tissue disease if it develops after age 30, if it is severe, and if it is accompanied by other symptoms (such as skin changes and arthritis).

12. Scleroderma scleroderma What is scleroderma? How common is scleroderma? What are the warning signs of scleroderma? What causes scleroderma? http://www.arthritis.ca/types of arthritis/scleroderma/default.asp?s=1

13. I HAVE SCLERODERMA Stories of real people who have scleroderma. Living and coping with scleroderma. A site by people with scleroderma, for people with scleroderma. http://www.ihavescleroderma.com/

Our stories: Email your story Art Excuse me Links Post its Post it archives Who we are Privacy statement Get a bumpersticker ... Translation New on our site... Diffuse stories: Eve I have been fighting for so long trying to understand what has been going on now I'm just scared. I would like to hear about women that have had children with scleroderma. Finally I feel like my life is turning around a little. Sharsheen I left the doctor's office that night believing I was about to die! CREST/Limited stories: Ana It gave me the courage to fight for my life even harder. Michelle Then the sore wouldn't heal 5 months or so. Mackenzie I was diagnosed with scleroderma,raynauds phenomenon,and ra when i was 15. Wanda I have improved over the years, but things are still tough. Joanne I remember thinking "That's the last disease I would ever want" Morphea/linear stories sfoltyn The whole thing gets quite complex. Preetham At first, I didn’t know what scleroderma was exactly. Visit our Cafe Press store all proceeds go to scleroderma research and support Search Amazon.com

14. Scleroderma Research Foundation Information about the organization, research, mailing list and resources. http://www.srfcure.org/

15. Scleroderma: Autoimmune Disorders Of Connective Tissue: Merck Manual Home Editio scleroderma (systemic sclerosis) is a chronic disorder characterized by degenerative changes and scarring in the skin, joints, and internal organs and by http://www.merck.com/mmhe/sec05/ch068/ch068c.html

Search Recent Searches Index Sections A B ... view all sections In This Topic Scleroderma Symptoms Diagnosis Prognosis and Treatment ... Back to Top Section Bone, Joint, and Muscle Disorders Subject Autoimmune Disorders of Connective Tissue Topics Introduction Eosinophilic Fasciitis Mixed Connective Tissue Disease (MCTD) Polymyositis and Dermatomyositis ... Relapsing Polychondritis Scleroderma Sj¶gren's Syndrome Systemic Lupus Erythematosus (SLE) Scleroderma drawAdBox(adPath, numberOfAds, false); Buy the Book Print This Topic Email This Topic Pronunciations angiotensin biliary cirrhosis corticosteroid ... telangiectasia Scleroderma (systemic sclerosis) is a chronic disorder characterized by degenerative changes and scarring in the skin, joints, and internal organs and by blood vessel abnormalities. The cause of scleroderma is not known. The disorder is 4 times more common in women than in men and is rare in children. Symptoms of scleroderma may occur as part of mixed connective tissue disease, and some people with mixed connective tissue disease develop severe scleroderma. Symptoms The usual initial symptom of scleroderma is swelling, then thickening and tightening of the skin at the ends of the fingers. Raynaud's phenomenon, in which the fingers suddenly become very pale and tingle or become numb and/or painful in response to cold or emotional upset (see

16. SCOT Study | Scleroderma: Cyclophosphamide Or Transplantation SCOT (scleroderma Cyclophosphamide or Transplantation) is a clinical research study, designed for people with severe forms of scleroderma, that compares http://www.sclerodermatrial.org/

Skip to content navigation: Home What is Scleroderma? What is a Clinical Research Study? For Interested Participants ... News First Published: 08/09/05 Last Modified: 05/11/07 SCOT Study What is SCOT? (sidebar) Stem Cells in the News If you read or listen to the news, you've probably heard about stem cell research. It is important to understand that the stem cells being used in the SCOT study will come from each participant's own body (adult blood stem cells). The SCOT study does not involve embryonic stem cells (stem cells from embryos). (end sidebar) SCOT is a clinical research study designed for people with severe forms of scleroderma . SCOT stands for Scleroderma: Cyclophosphamide Or Transplantation . The SCOT study will compare the potential benefits of stem cell transplant and high-dose monthly cyclophosphamide (Cytoxan) in the treatment of scleroderma. These 2 approaches are investigational which means that they are still being tested in research studies and are not approved by the U.S. Food and Drug Administration (FDA) for the treatment of scleroderma. If you decide to participate in SCOT, you will receive 1 of the following: Stem cell transplantation High-dose monthly Cytoxan : Participants will receive high doses of intravenous Cytoxan, a chemotherapy drug often used to treat cancer.

17. What You Need To Know About Scleroderma scleroderma is a chronic, although rare, autoimmune disease in which normal tissue is replaced with dense, thick fibrous tissue. Normally, the immune system http://www.clevelandclinic.org/arthritis/treat/facts/scleroderma.htm

What You Need to Know About Scleroderma What is scleroderma? Scleroderma is a chronic, although rare, autoimmune disease in which normal tissue is replaced with dense, thick fibrous tissue. Normally, the immune system helps defend the body against disease and infection. In patients with scleroderma, the immune system triggers other cells to produce too much collagen (a protein). This extra collagen is deposited in the skin and organs, which causes hardening and thickening (similar to the scarring process). Although it most often affects the skin, scleroderma also can affect many other parts of the body including the gastrointestinal tract, lungs, kidneys, heart, blood vessels, muscles and joints. Scleroderma in its most severe forms can be life-threatening. Forms of scleroderma There are two major forms of scleroderma, localized and systemic. Systemic scleroderma again is of two main types: diffuse and limited. Localized scleroderma The more common form of the disease, localized scleroderma, affects only a person's skin, usually in just a few places. It often appears in the form of waxy patches or streaks on the skin, and it is not uncommon for this less severe form to go away or stop progressing without treatment. Diffuse scleroderma As its name implies, this form affects many parts of the body. Not only can it affect the skin, but it also can affect many internal organs, hindering digestive and respiratory functions, and causing kidney failure. Systemic scleroderma can sometimes become serious and life-threatening.

18. SCLERODERMA FAQ The scleroderma FAQ is a comprehensive document about scleroderma and CREST targeted at patients,family members, and physicians. http://www.synnovation.com/sclerodermafaq.html

SCLERODERMA F.A.Q. Minor Revision 3/1/2008 Please address all comments and suggestions to: Ed Harris eharris@synnovation.com General Description Scleroderma (means "hard skin") is a rare connective tissue disorder characterized by abnormal thickening of the skin. It is generally considered to be an autoimmune disorder. There are two major variants of the disease, as well as other less common forms. The more serious form is usually called "diffuse Scleroderma" and is characterized by rapid development of skin thickening beginning with the hands, and face and extending to the arms and trunk. People with diffuse Scleroderma are at greater risk for developing internal organ involvement early in the course of the disease. The other major form is often called limited Scleroderma or CREST Syndrome. The name CREST is an acronym for its characteristic symptoms: calcinosis Raynaud's phenomenon, esophageal involvement, sclerodactyly , and telangiectasia (these terms are discussed below). This form progresses more slowly and has a better prognosis. Scleroderma can also occur in more localized forms without internal organ involvement. These variants are called

19. Scleroderma - Symptoms, Treatment And Prevention scleroderma is a chronic, degenerative, autoimmune disorder that leads to the overproduction of collagen in the body s connective tissue. http://www.healthscout.com/ency/68/311/main.html

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20. Johns Hopkins Scleroderma Center | Scleroderma Symptoms | Scleroderma Treatment Sclerodmera information for patients and physicians including information on scleroderma symptoms, treatment and research. http://scleroderma.jhmi.edu/

About the Center What is Scleroderma? For Patients Information about visiting the center and living with Scleroderma. For Physicians Information about new advances, referral instructions, and online resources. Research We have over 20 Scleroderma research programs underway and many more planned. How to Make an Appointment How to Refer a Patient Contact Us Donate scleroderma: a manageable disease Scleroderma is a rheumatic autoimmune disease that causes hardening of the skin and other tissues of the body. Early symptoms include Raynaud's phenomenon. Although Scleroderma is chronic, it can be treated successfully. about the scleroderma center The Johns Hopkins Scleroderma Center specializes in the care of patients with scleroderma and related conditions. Our doctors are attending physicians and full time faculty members at the Johns Hopkins University School of Medicine. new advances in therapy Publications Clinical Trials Translational Research Home ... Site Map

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