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Enter your search terms Submit search form Web open-site.org home log in apply to edit help ... Organic Chemistry : Combinatorial Chemistry Overview Combinatorial chemistry (combinational chemistry or сombichem) - Is used to synthesize large number of chemical compounds by combining sets of building blocks. Each newly synthesized compound's composition is slightly different from the previous one. A traditional chemist can synthesize 100-200 compounds per year. A combinatorial robotic system can produce in a year thousands or millions compounds which can be tested for potential drug candidates in a high-throughput screening process. Array Synthesis Form of parallel synthesis in which the reaction vessels are maintained in a specified spatial distribution, e.g. the wells of a 96-well plate or pins held in a rack. Assay: An assay is a reproducible procedure for testing a particular reaction. In the drug discovery process, assays must be developed in order that candidate drugs can be screened for their effect on the drug target. Building Block One of a number of interchangeable reagents which can be used in combinatorial library synthesis, part of the structure of which becomes incorporated into the final product, i.e. its residue.

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