1. Biography Center : Biographies Of Robert Bruce Merrifield In Biographies of Merrifield Robert Bruce and, for more detail Biography of , , http//nobelprize.org/nobel_prizes/chemistry/laureates/1984/index.html, http://www.biography-center.com/biographies/2190-Merrifield_Robert_Bruce.html

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3. Merrifield Robert Bruce - WIEM, Darmowa Encyklopedia Merrifield Robert Bruce (ur. 1921), biochemik ameryka ski, od 1966 profesor Uniwersytetu Rockefellera w Nowym Jorku, cz onek Narodowej Akademii http://portalwiedzy.onet.pl/46718,,,,merrifield_robert_bruce,haslo.html

Szukaj Poczta Onet.pl Wiem: ... Encyklopedie Start Kalendarium Twój notes S³owniki Kursy ... TVN Lingua Sklep Szukaj w Onet.pl merrifield robert bruce katalog.onet.pl Informacje o serwisie Kursy on-line Napisz do nas O nas Pomoc ... Aktualizacja encyklopedii wszystkie encyklopedia prawa wielka ksiêga imion s³ownik informatyczny Poka¿ tylko zdjêcia, filmy i mapy Jak szukaæ? Merrifield Robert Bruce Dodaj do notesu Chemia, Biologia, Ameryka Pó³nocna, Stany Zjednoczone Merrifield Robert Bruce (ur. 1921), biochemik amerykañski, od 1966 profesor Uniwersytetu Rockefellera w Nowym Jorku, cz³onek Narodowej Akademii Nauk w Waszyngtonie. Prace g³ównie z syntezy polipeptydów. Za opracowanie prostej i szybkiej, zautomatyzowanej laboratoryjnej metody syntezy ³añcuchów polipeptydowych (w du¿ych ilo¶ciach, na tzw. sta³ej matrycy) otrzyma³ w 1984 Nagrodê Nobla w dziedzinie chemii. Metoda Merrifielda jest obecnie stosowana zarówno w laboratoriach, jak i zak³adach przemys³owych. Odwied¼ w Internecie: Docent OnLine Zobacz równie¿: Biosynteza bia³ka Inne na ten temat: Nobla Nagrody, 1981-1985

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var s_account="msnportalencartafr"; Imprimer Merrifield, Robert Bruce Format lecture Dans le menu Fichier, cliquez sur Imprimer. Merrifield, Robert Bruce Pr©sentation Merrifield, Robert Bruce (1921-2006), biochimiste am©ricain, laur©at du prix Nobel de chimie en 1984, pour sa mise au point d’une m©thode de synth¨se permettant la fabrication industrielle d’hormones ou d’enzymes. Parcours universitaire N©   Fort Worth (Texas), Robert B. Merrifield effectue des ©tudes de chimie   l’universit© de Californie   Los Angeles (UCLA). Jeune dipl´m©, il est engag© par un laboratoire de biochimie. Il s’aper§oit tr¨s vite de ses limites dans ce domaine et d©cide de retourner   l’universit© pour approfondir le sujet. Il obtient son doctorat de biochimie en 1949, et rejoint aussit´t l’Institut de recherche m©dicale Rockefeller (actuellement universit© Rockefeller)   New York, o¹ il effectue toute sa carri¨re (de postdoctorant   professeur titulaire en 1966). Travaux scientifiques Les travaux de Robert B. Merrifield concernent la synth¨se des prot©ines. Celles-ci sont des cha®nes d’acides amin©s connect©s entre eux par des liaisons peptidiques. Les peptides ont la mªme structure que les prot©ines, mais leurs cha®nes d’acides amin©s sont plus courtes. Partant de leurs constituants chimiques, on peut cr©er des peptides, puis fabriquer des prot©ines enti¨res. Avant que Robert B. Merrifield ne mette au point une nouvelle m©thode de synth¨se dans les ann©es 1950, ce processus ©tait fastidieux et tr¨s long. Pour que les acides amin©s s’associent dans le bon ordre, il fallait bloquer certaines parties, afin que seuls les sites voulus interagissent et se connectent. Entre chaque ©tape, le peptide devait ªtre isol© et purifi©. Lorsqu’on ©liminait les sous-produits de la r©action pr©c©dente, on perdait irr©m©diablement une partie de la structure du peptide.

5. Merrifield, Robert Bruce - MSN Encarta Translate this page Merrifield, Robert Bruce (*1921), amerikanischer Biochemiker und Nobelpreisträger. http://de.encarta.msn.com/encyclopedia_721551139/Merrifield_Robert_Bruce.html

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var s_account="msnportalencartait"; Stampa Merrifield, Robert Bruce Articolo Per stampare le informazioni, scegliere Stampa dal menu File. Merrifield, Robert Bruce Merrifield, Robert Bruce (Fort Worth, Texas 1921), biochimico statunitense. Svilupp² un metodo per la sintesi chimica su supporto solido delle proteine che diminu¬ drasticamente il tempo necessario a compiere questo processo (da alcuni mesi a pochi giorni), permettendo ai ricercatori di incrementare lo sviluppo di anticorpi sintetici e di vaccini. Per il suo contributo alla sintesi delle proteine, Merrifield fu insignito del premio Nobel per la chimica nel 1984. Merrifield si laure² in chimica all’Universit  della California a Los Angeles nel 1949. Nello stesso anno si trasfer¬ al Rockefeller Institute for Medical Research (ora Rockefeller University) a New York, dove rimase per tutta la carriera. Le proteine sono costituite da catene di amminoacidi tenuti uniti da legami peptidici. I peptidi hanno la stessa struttura delle proteine, ma sono costituiti da catene di amminoacidi pi¹ brevi. Gli scienziati sintetizzano artificialmente peptidi per produrre intere proteine. Prima che Merrifield, alla fine degli anni Cinquanta, sviluppasse la nuova tecnica, il processo era lungo e tedioso. Per ottenere che gli amminoacidi si legassero nella corretta sequenza, certe parti dovevano essere rese inattive in modo che solamente i siti desiderati potessero interagire e legarsi. Tra un passaggio e l’altro, il peptide doveva venire isolato e purificato. Quando i sottoprodotti della reazione precedente venivano eliminati, ineluttabilmente parte della struttura del peptide andava persa.

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